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Meprobamate
Meprobamate was introduced as an anti-anxiety agent in 1955 and
is prescribed primarily to treat anxiety, tension, and
associated muscle spasms. More than 50 tons are distributed
annually in the United States under its generic name and brand
names such as Miltown® and Equanil®. Its onset and duration of
action are similar to the intermediate-acting barbiturates;
however, therapeutic doses of meprobamate produce less sedation
and toxicity than barbiturates. Excessive use can result in
psychological and physical dependence. Carisoprodol (Soma®), a
skeletal muscle relaxant, is metabolized to meprobamate. This
conversion may account for some of the properties associated
with carisoprodol and likely contributes to its abuse.
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